Russian VX: Inhibition and Reactivation of Acetylcholinesterase Compared with VX Agent
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منابع مشابه
Evidence for nonacetylcholinesterase targets of organophosphorus nerve agent: supersensitivity of acetylcholinesterase knockout mouse to VX lethality.
The possibility that organophosphate toxicity is due to inhibition of targets other than acetylcholinesterase (AChE, EC 3.1.1.7) was examined in AChE knockout mice. Mice (34-55 days old) were grouped for this study, after it was determined that AChE, butyrylcholinesterase (BChE), and carboxylesterase activities had reached stable values by this age. Mice with 0, 50, or 100% AChE activity were t...
متن کاملInhibition of antibiotic efflux in bacteria by the novel multidrug resistance inhibitors biricodar (VX-710) and timcodar (VX-853).
Inhibitors of mammalian multidrug efflux, such as the plant alkaloid reserpine, are also active in potentiating antibiotic activity by inhibiting bacterial efflux. Based on this precedent, two novel mammalian multiple drug resistance inhibitors, biricodar (VX-710) and timcodar (VX-853), were evaluated for activity in a variety of bacteria. Both VX-710 and VX-853 potentiated the activity of ethi...
متن کاملProlonged Inhibition of Motor Activity following Repeated Exposure to Low Levels of Chemical Warfare Agent Vx
While neurobehavioral effects of acute exposure to toxic levels of chemical warfare nerve agents (CWNA) have been characterized (e.g. [8]), much less is known about the effects of repeated exposure to non-convulsive levels of CWNA. In Exp. 1, male mice that received repeated exposure (1/day x 5 days/wk x 2 wk) to 0.4 LD50 of the nerve agent VX had much lower activity in the home cage, relative ...
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Cystic fibrosis (CF) is a lethal recessive genetic disease caused primarily by the F508del mutation in the CF transmembrane conductance regulator (CFTR). The potentiator VX-770 was the first CFTR modulator approved by the FDA for treatment of CF patients with the gating mutation G551D. Orkambi is a drug containing VX-770 and corrector VX809 and is approved for treatment of CF patients homozygou...
متن کاملDegradation and Decontamination of Vx in Concrete
Reactions of VX in concrete have been studied in situ using solid state P NMR. The size of VX drops deposited on concrete affect the natural degradation rate, with 4 μL drops reacting faster than 0.2 μL drops. Water added to concrete samples containing sorbed VX to mimic precipitation and/or a potential decontamination strategy resulted in the desorption of copious amounts of VX into the water ...
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ژورنال
عنوان ژورنال: Basic <html_ent glyph="@amp;" ascii="&"/> Clinical Pharmacology <html_ent glyph="@amp;" ascii="&"/> Toxicology
سال: 2006
ISSN: 1742-7835,1742-7843
DOI: 10.1111/j.1742-7843.2006.pto_267.x